I've been running into this issue for a couple of months. I reported it to Microsoft and tried basically every solution I could find – to no avail.
On the Meraki side, I am also running firmware MX 15.42.1. I
As for the PCs, I am running two identical laptops with identical network cards. One with Win10 Pro and one with Win11 Pro.
On the Windows 10 machine, VPN speeds are consistent and reliable.
On the Windows 11 machine, I have always had decent (not great, but workable) VPN download speeds (~10Mbps). But my VPN upload speeds were unworkable - less than .25Mbps that's if I could even hold an upload connection long enough to run a test.
Up until today, that had been consistent since the day I installed Windows 11 (more than 2 months ago). I've been running Windows 11 Insider Preview 10.0.22000.100 since 8/4/2021.
Today, I downloaded 2021-08 Cumulative Update for Windows 11 for x64-based systems (KB5005191). Restarted. Uninstalled/Reinstalled a few things (Device Manager -> Network Adapters -> WAN Miniport (IP), WAN Miniport (IPV6) and WAN Miniport (PPTP)). Restarted.
Now, I have a workable and mostly reliable ~10Mbps up and ~10Mbps down.
I had been fighting this for months as most of my usage involves a work VPN rendering my Win11 PC unusable. I'm pretty happy I can finally start using Windows 11 as my primary.
Hope this helps someone else.