It looks like this fixed it HKEY_LOCAL_MACHINE\SYSTEM\CurrentControlSet\Services\PolicyAgent RegValue: AssumeUDPEncapsulationContextOnSendRule Type: DWORD Value data: 2 Base: Decimal
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Similar things had happened to my environment when I turned on content filtering and threat protection on spoke and hub at the same time. I turned them off on the Hub and it went away.
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You need to use a comma between the CIDR notations. Ex. "192.168.1.5,172.16.0.0/12". Please see see this document https://documentation.meraki.com/MX-Z/NAT_and_Port_Forwarding/Troubleshooting_Port_Forwarding_and_NAT_Rules
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