The ISE will help that each user/device will get the right classification for the segmentation. The needed Device depends on the Security you want to have: For Basic L3 control, a L3 switch could do the job. For Advanced L3/L4 control I would go for a Firewall like the ASA running on a Firepower platform. For L7 control we need a NGFW/IPS. For some implementations I place the routing on the MX with Adv. Security License, but only when most of the traffic is going to the cloud anyway. If there is a very high amount of local User/Server-Traffic I typically use FTD on a Firepower platform as the throughput per $ is better compared to the Meraki MX (even with HA). And there are better ways to integrate it.
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