I was also wondering if this works. I am looking into buying two MS450 and use them in a stack stretched across two server rooms for redundancy.
With the front plane stacking I expect it to work like the Catalyst 9500 virtual stacking and I think I've seen that setup working at one of my former customer sites. (But don't quote me on that)
Maybe open a case with Meraki and ask if this is something that works and is supported? The stacking cables are just QSFP cables so I don't see why a fiber module shouldn't work.
Do you mean the front 100G ports? These are for uplinks only, the 450's don't support Flexible Stacking so I would have to use the back Stacking ports and I'm just wondering if 100G QSFP's would work in place of the Stacking Cables.