>Is it possible to configure Meraki APs to authenticate Wi-Fi clients solely based on client certificates without involving a RADIUS server?
Yes. You use local authentication mode, set to certificate authentication.
https://documentation.meraki.com/MR/Encryption_and_Authentication/Meraki_Local_Authentication_-_MR_8...
>If yes, what are the steps or best practices to achieve this?
You 'll need to subscribe to Cloud PKI. Tere is a long there here about doing it:
https://community.meraki.com/t5/Wireless/Azure-Cloud-PKI-is-now-released-how-do-we-hook-Meraki-AP-to...
>Does Meraki support any native certificate-based authentication mechanisms in a serverless configuration?
Yes. It is called Trusted Access. It uses a Systems Manager licence. Users can authenticate against Entra ID in the self service portal, deploy a certificate to their device, and then use that to authenticate.
https://documentation.meraki.com/General_Administration/Cross-Platform_Content/Trusted_Access_for_Se...
>Are there specific configurations in Intune or Meraki that need attention to streamline this setup?
It depends on weather you want to use Cloud PKI or Trusted Access.