Have you got "Opt-in to view and manage alerts in a new centralized Alert Page" enabled under Organisation/Early Access?
If so - I think this has a bug at the moment, and if you turn it off the alerts will go away (I think they are a false positive).
Failing that, do any of the switch ports show there is a blocked connection to another switch (indicating a loop somewhere)?
>Should I try to enable BPDU Guard on all access ports network wide?
Have you definitely got the ports configured as access ports, as opposed to trunk ports?
I don't see any harm in enabling BPDU guard if the above is already done.