Thank you both @cmr and @PhilipDAth,
We have a relatively simple topology.
The 425s are at the core of this site and stacked and providing Layer 3 switching, which are then each connected to separate CPE MikroTik (VRRP Warm Spare) routers with static routes over 1/1Gbps NCS connections connecting back to the core of the network.
Then we have about 30 x 225 edge switches LACP'd back to the 425 core stack.
Edge wise, just about all devices and system are workstations with the odd IP camera and UPS powering the switches.
All our servers and core systems are upstream at datacentres.
So I'm somewhat convinced it should be fine to drop the MTU down. I don't even recall setting the MTU to 9578 in the first place. Maybe the MTU size came over from the Catalyst migration to Meraki but there are no more Catalysts in play in this site.
I might drop it down to the max compat size of 9416, given that there is a fair amount of routing going on and therefore might have some encapsulation/extra-stuff going on.