Hey adten!
Method 1 in the documentation UCcert linked is gonna be your best bet. Meraki spoke configurations point to a particular hub network on the dashboard, and ultimately don't care which model MX is within that network. As long as you add the new MX450 to the same network that the old MX100 was in, all of the spokes will re-negotiate their tunnels to the Public IP and Port of the new MX450. Overall the only change that is made is which hardware serial is claimed to your Hub network and turning VPN back "on" for that network, the spoke configurations will be left alone.
Let me know if you have any other questions!
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