I have a recent version of Win 10 Pro (1809 OS build 17763.864), BitDefender Total Security with default browser set to Edge Beta Version 79.0.309.18 (Official build) beta (64-bit). All the Office365 applications are 32/64-bit Office2016, kept current.
Currently, I am at Institute A, a world leading Health Research organisation, with effing awful IT infrastructure, out of date and insecure software and a really bad attitude towards addressing these issues. My laptop is connected to their poorly set up WiFi, but I'm not unduly worried as Office365 sets up an encrypted link to the remote services. Until it all goes titsup (technical engineering term, much used by Grace Hopper). BitDefender and Office apps throw a wobbly to do with Azure/Exchange/Office cert inconsistencies, many web sites become unreachable (including Meraki). What brings this on - setting the laptop to sleep; on waking all hell breaks out. Fixing it required restarting, forgetting the WiFi site, doing an offline Office365 repair and briefly switching to Chrome. This took a very long time to fix.
Next door is Institute B, another world leading Health Research organisation. Where i am based, I have the choice of connecting to either Institute's WiFi. I never have these issues with Institute B.
So, in my case, a problem that sounds very like yours is triggered by really crap network infrastructure and software. I'm not implying anything about other people's systems.
Hopefully, my experience has given you some clues.
Note expletives have been deleted; there may be some remaining technical terms that somewhat resemble expletives, but by general accord and usage they terms commonly encountered in network engineering.