Instagram does not provide a direct feature to block specific profile URLs. However, you can take certain steps to limit interaction with a specific profile:
You can block a specific user on Instagram. This will prevent them from seeing your content and messaging you. To do this, go to their profile, tap the three dots in the top right corner, and select "Block".
If your account is private, only approved followers can see your posts and stories. Go to your profile, tap on the three lines in the top right corner, go to "Settings", then "Privacy", and toggle on "Private Account".
You can restrict a user, which means their comments on your posts will only be visible to them. They won't know that they've been restricted. To do this, go to their profile, tap the three dots in the top right corner, and select "Restrict".