Hi Bundy, In order for Windows10Pro clients to work with profiles (Systems Manager, Settings), you will need to enroll in MDM. For the clients that matter to us (560+ Windows 10 Pro clients), we do both Agent Install and MDM enrollments. We are enrolling in MD with AD user auth (configured at Systems Manager, scroll to user auth settings).
Using both means of enrollment allow us to take advantage of Profiles for VPN and SSID settings push along with pushed apps (Systems Manager, Apps).
While there are a number of issues with Windows10Pro and its "compatibility" and support with SM, we seem to have a workable management system for our endpoints.
Hopefully this is useful information you and your Windows 10 Clients.
My largest complaint is that the process for users to enroll is not simple. Much of this is MS fault but the burden should fall on Meraki SM because we pay them for this tool,.. or they shouldn't even support SM for Windows10 in the first place. I have had my frustrations with Meraki Support. Though that is a entirely different discussion.