Hi, You need to allow traffic between your subnet and the Microsoft cloud and the link provided by @AjitKumar has all the details you may need to configure rules on the MX. You can find a full list of Office 365 and SfB addresses and ports here: https://support.office.com/en-us/article/office-365-urls-and-ip-address-ranges-8548a211-3fe7-47cb-abb1-355ea5aa88a2?ui=en-US&rs=en-US&ad=US
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