You are almost certainly experiencing an MSS squeeze. If you have a Windows client you can determine the maximum MTU by using a ping command like this:
ping <app server> -f -l 1400
If the ping works, increase the size (above 1400). If it fails, reduce the number. Keep going to you get the maximum size that works.
What OS is the App Server running? I can probably suggest the command to run to adjust the MSS or MTU on that side to resolve the issue.