If you are using split-tunnel yes, otherwise no.
Client Routing: This is used to specify full or split-tunnel rules pushed to the AnyConnect client device. You can send all traffic through VPN, all traffic except traffic going to specific destinations, or only send traffic going to specific destinations.
https://documentation.meraki.com/MX/Client_VPN/AnyConnect_on_the_MX_Appliance#How_to_Enable_AnyConne..._Dashboard
You can also apply this via Group Policy.
I am not a Cisco Meraki employee. My suggestions are based on documentation of Meraki best practices and day-to-day experience.
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