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Is it possible to upload the M365 JSON file that has all of the IP address that need to be unblocked\blocked to the config for an MX450? If so How?
Block where? Firewall? Url filter?
MX does not block outgoing traffic by default.
Most things you can script using the API.
https://developer.cisco.com/meraki/api-v1/#!get-network-appliance-firewall-firewalled-services
As @ww says - you probably don't need to do anything. Are you experiencing a problem or is something not working?