Did you ever get a resolution to this
I have similar problem
Hub and spoke on 18.107.10
Latency 34ms
Hub 1Gbps symmetric circuit
Spoke 300Mbps symmetric circuit
Internet access from Spoke via Hub with central breakout
Internet access good speeds and upload/downloads to Onedrive good
Windows SMB (V3) file shares upload from spoke to hub good
downloads from Hub to spoke very slow
All other applications appear good.