I don't think there is a way to block a specific address or subnet in a NAT rule.
You could drop them in the web server though, right? And I guess you could put something upstream with ACL's to block specific IP addresses.
Do you have advanced security license? You maybe able to do something there.
I have a similar situation with a FTPS server I maintain to send customer backups to. It uses port 22 and gets hammered all day, every day. I configured my server to block specific addresses and it also has a feature to auto block multiple failed attempts.
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