I got a response from Meraki and they said to shut it off and turn it back on again. That did solve the issue and the issue didn't reoccur but that doesn't explain why it happened in the first place. The only thing I can think of is since it was a HUB, even though nobody used it for connections, that it had to be depreciated to a SPOKE and then you could make these kinds of changes. To be fair, the system did warn me to some extent as in "Changing the DDNS hostname will force the device to fetch a new AnyConnect VPN device certificate so please change this setting sparingly." I just think they could reword it since nothing happened to my AnyConnect, but my worldwide S2S links died because of it. ... View more