First of all you should know that nearly all clients are 2x2. Only a small number of clients are 3x3 (examples are MacBook Pro's).
The MR42 is 3x3. The MR53 is 4x4. The MR55 is 8x8.
On the whole I don't like mixing different generations of WiFi technology. I've had issues where a client is (say) wave2 compatible, and it can see a wave2 AP a long way away and stays attached to it even though the user is standing next to a wave1 AP.
At least in this case they are both 802.11ac - so the issue may not be as pronounced.
Also the WiFi6 APs are out now, so check out the MR45.
I typically use MR33 for guest WiFi. I typically use MR42/MR45 in non-dense office environments. I typically use the MR53/MR55 in dense office environments.