It's always something you can do but I would be careful.
The goal with channels is to get as much spectrum re-use as you can, so people tend to lean towards 20MHz by default as this allows you to have the most non-overlapping channels on 5GHz.
If you start to mix stuff, and your letting AutoRF handle it, its easily possible that an AP might be running 40 or 80MHz (say starting on channel 36), and the AP nearby (or within ear-shot) might be on channel 40.
So those two access points might now be contending for the same RF space.
If you know you can get away with it, and you've controlled which channels those RF profiles will be using, then you should be fine. Just make sure you put in the effort to ensure your not stepping on your own toes.