If you have two uplinks and want both to be able to carry IPv6 traffic (with failover), you would typically set Auto.
If one uplink should never carry IPv6 traffic (for specific routing / security reasons), you would set it to Disabled.
The Manual setting allows network administrators to specify IPv6 addresses manually.
You can configure Manual prefixes if your ISP doesn’t support DHCPv6-PD or if you are using your own Independent Prefix space. The MX will in turn automatically assign /64 prefixes to each VLAN as configured and available.
IPv6 Support on MX Security & SD-WAN Platforms - Core Fundamentals
IPv6 Support on MX Security & SD-WAN Platforms - LAN
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