Well, it would probably take me 60 to 120 minutes to setup if I limit myself to two coffee breaks. If you are not familiar with all the steps it could take a day or two.
And if you mess up the access policy you can cut yourself off (as in, no matter where you plug into the network it will refuse you access).
If your RADIUS servers become unavailable you can be cut off (hint - dual NPS/RADIUS servers is a really good idea).
Perhaps I am being overly negative. What you could do is setup half a dozen ports on a switch with the access policy and get it working perfectly there before a wider roll out.
Note you can do 802.1x on MX's as well. In your case I would do it on the switches.