Yes sir, leave that unchecked to stay protected.
This would disallow the use of multiple profiles or certificates on a device. You can have multiple payloads on a device to manage it, this would just disallow a user from allowing another source to manage the device. Try googling "malicious profiles ios" and you will see what this button is used to deter from.
So it would be best to have it unchecked then ?
Yes sir, leave that unchecked to stay protected.
Unfortunately, we cannot do that because our users install profiles that we make available to them to join WiFi networks.
I wish Meraki would let us set up a policy to see that only whitelisted profiles are installed.
@DCooper Is correct about that specific restriction. As a side note, that does not impact Meraki from installing any profiles.
If you are asking what supervised does, it just allows you as an admin to push more settings to the device. Supervision can be done via Apple Configurator 2 or DEP (which is now mandatory).
Jared