On the whole, yes. You'll still be able to do things like app deployments and policies.
An example of something you won't be able to do is say automatically deploy wifi network "x" without having to say anything else because it already knows the wifi settings. Instead, you have to say deploy wifi "x" using WPA2-Enterprise mode, etc.
Basically things it would normally be able to learn from the network you will have to manually specify.
You also won't be able to use some of the automatic security features, like Sentry.
https://documentation.meraki.com/MR/MR_Splash_Page/Systems_Manager_Sentry_Enrollment