The most effective way I see to block the application is via the Machine's Firewall.
If you have Trellix or any other corporate firewall that users do not have access to, you can block the application without any difficulty.
I hope I have helped you.
I am not a Cisco Meraki employee. My suggestions are based on documentation of Meraki best practices and day-to-day experience.
Please, if this post was useful, leave your kudos and mark it as solved.